Fri Dec 23 2022

110 articles - From Friday Dec 16 2022 to Friday Dec 23 2022

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Gastrointest Endosc

American Society for Gastrointestinal Endoscopy guideline on post-ERCP pancreatitis prevention strategies: methodology and review of evidence.

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American Society for Gastrointestinal Endoscopy guideline on post-ERCP pancreatitis prevention strategies: summary and recommendations.

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Meta-analysis

meta-analyses and systematic reviews

Aliment Pharmacol Ther

Meta-analysis: Efficacy and safety of albumin in the prevention and treatment of complications in patients with cirrhosis.

Albumin may reduce mortality risk in cirrhotic patients with SBP or HE. No benefit was identified in reducing liver transplants or SAEs. Long-term administration may be associated with a lower risk of cirrhosis complications and need for paracentesis.

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Endosc Int Open

Endoscopic sphincterotomy vs papillary large balloon dilation vs combination modalities for large common bile duct stones: a network meta-analysis.

Based on network meta-analysis, ESLBD seems to be superior with higher SCR and lower need for ML and AEs for large CBD stones.

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Gut

Production and possible reduction of greenhouse gases produced during GI endoscopy activity: a systematic review of available literature.

Recognition of carbon emissions generated by GI endoscopy activity is critical. Although multiple limitations exists for quantification of these emission, there is an urgent need for collecting proper data as well as examining novel methods for reduction of these emissions for a sustainable endoscopic practices in the future.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Aliment Pharmacol Ther

A practical use of noninvasive tests in clinical practice to identify high-risk patients with nonalcoholic steatohepatitis.

The use of this simple clinical algorithm can identify and assist in managing patients with NAFLD at high risk for adverse outcomes.

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Effectiveness and safety of risankizumab induction therapy for 100 patients with Crohn's disease: A GETAID multicentre cohort study.

In a cohort of highly refractory patients with luminal CD and multiple prior drug failures including ustekinumab, risankizumab induction provided a clinical response in about 3 out of 4 patients and steroid-free clinical remission in about half of patients.

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Predictors of disease activity during pregnancy in women with inflammatory bowel disease-a Danish cohort study.

Predictors for disease activity include disease activity in a previous pregnancy and/or prior to conception, as well as UC phenotype. Reassuringly, women with IBD in remission are not at increased risk of adverse pregnancy outcomes.

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Prevalence and prognostic significance of vitamin C deficiency in patients with acute upper gastrointestinal bleeding: a prospective cohort study.

VCD is highly prevalent in patients with UGIB and associated with poorer outcomes, including higher mortality, rebleeding and length of stay. Interventional studies are required to determine the impact of early Vitamin C supplementation on clinical outcomes.

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Am J Gastroenterol

Consumption of two green kiwifruit daily improves constipation and abdominal comfort - results of an international multicentre randomised controlled trial.

This study provides original evidence that the consumption of a fresh, whole fruit has demonstrated clinically relevant increases in CSBM and improved measures of GI comfort constipated populations. Green kiwifruit are a suitable dietary treatment for relief of constipation and associated GI comfort.

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Long-term outcomes of biological therapy in Crohn's disease complicated with internal fistulizing disease: BIOSCOPE study from GETECCU.

Biologic therapy is beneficial in approximately three quarters of patients with fistulizing CD, achieving fistula closure in 24%. However, around one third still undergo surgery due to refractory disease. Some patient and lesion-related factors can identify patients who will obtain more benefit from these drugs.

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Normative Values for Body Surface Gastric Mapping Evaluations of Gastric Motility Using Gastric Alimetry: Spectral Analysis.

This study provides normative reference intervals for BSGM spectral data to inform diagnostic interpretations of abnormal gastric function.

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Real-World Evidence Comparing Vedolizumab and Ustekinumab in Antitumor Necrosis Factor-Experienced Patients With Crohn's Disease.

This real-world comparative effectiveness study of anti-TNF-experienced patients with CD initiating vedolizumab or ustekinumab showed similar treatment persistence rates beyond 52 weeks, although secondary outcomes such as all-cause hospitalizations, nonsurgical CD hospitalizations, and hospitalizations for infection favored ustekinumab initiation. We, therefore, advocate for individualized decision making in this medically refractory population, considering patient preference and other factors such as cost and route of administration.

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Transpapillary Stenting Improves Treatment Outcomes in Patients Undergoing Endoscopic Transmural Drainage of Ductal Disruption-Associated Pancreatic Fluid Collections.

Transpapillary pancreatic duct stenting seems to improve the efficacy of endoscopic TMD of pancreatic duct disruption-associated PFCs by reducing the recurrence rate and shortening the length of hospital stay.

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Clin Gastroenterol Hepatol

Associations of Antibiotics, Hormonal Therapies, Oral Contraceptives, and Long-Term NSAIDs with Inflammatory Bowel Disease: Results from the Prospective Urban Rural Epidemiology (PURE) Study.

Antibiotics, hormonal medications, oral contraceptives, and long-term NSAID use were associated with increased odds of incident IBD after adjustment for covariates.

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Non-heavy alcohol use associates with liver fibrosis and 'nonalcoholic' steatohepatitis in the Framingham Heart Study.

In this community cohort, we demonstrate that non-heavy alcohol use associates with fibrosis and NASH, after adjustment for metabolic factors. Longitudinal studies are needed to determine the benefits of moderating alcohol use to reduce liver-related morbidity and mortality.

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Non-invasive assessment of postoperative disease recurrence in Crohn's Disease: a multicenter, prospective cohort study on behalf of the IG-IBD.

A non-invasive approach combining bowel US and FC can be used with confidence for detecting POR in patients with CD without the requirement for CS.

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Reduction in racial and ethnic disparity in survival following liver transplant for hepatocellular carcinoma in DAA era.

With the availability of DAA therapy, racial disparities in post-LT survival have improved.

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Endosc Int Open

A new system to prevent SARS-CoV-2 and microorganism air transmission through the air circulation system of endoscopes.

ENDOBOX SC prevents the increase in temperature induced by lamps and processors, allows access to al necessary connections into the endoscopic columns, and creates a sterile and positive pressure volume, which prevents potential contamination from microorganisms.

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Distinct gastric phenotype in patients with pathogenic variants in SMAD4: A nationwide cross-sectional study.

variants.

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Early phase trial of intracystic injection of large surface area microparticle paclitaxel for treatment of mucinous pancreatic cysts.

Intracystic injection of LSAM-PTX into mucinous PCLs resulted in no significant AEs, a lack of systemic absorption, and resulted in reduction of cyst volume over a 6 month period.

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Effect of adding acetic acid when performing magnifying endoscopy with narrow band imaging for diagnosis of Barrett's esophageal adenocarcinoma.

Using M-AANBI might improve the accuracy of BEA diagnosis.

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Endoscopic treatment of intussusception due to small intestine polyps in patients with Peutz-Jeghers Syndrome.

Endoscopic treatment of intussusception is feasible to avoid laparotomy in patients with Peutz-Jeghers syndrome.

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Endoscopy training in the Netherlands: a national survey among gastroenterology residents.

Although most gastroenterology residents were satisfied with the endoscopy training program and endoscopy supervision in their teaching hospital, this study identified considerable local and regional variability. Future studies should be conducted to evaluate the trainers' perspective and trainers' behavior during endoscopy training sessions, which might eventually lead to the development of best practices regarding endoscopy training, including standardization of training programs and supervision methods.

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Feasibility of progressive polyp contraction with underwater endoscopic mucosal resection in =20mm superficial colorectal lesions.

PP-CUE is useful to resect superficial non-polypoid colorectal lesions 20 to 25mm in diameter in an en bloc fashion.

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Frequency and nature of endoscopic and pathologic errors leading to referral for endoscopic resection to a tertiary center.

Endoscopists at tertiary centers should expect referrals to clarify the nature of colorectal lesions as neoplastic or non-neoplastic. Community endoscopists with equivocal endoscopic findings and unexpected or equivocal pathology results can consider pathology review at their center or at an expert center before referral for endoscopic or surgical resection.

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Implementation of the Aldrete score reduces recovery time after non-anesthesiologist-administered procedural sedation in gastrointestinal endoscopy.

Implementation of the Aldrete score after procedural sedation and analgesia significantly reduces the time spent in the recovery area. The score can be used to safely implement a discharge policy that provides more efficient and standardized management for an endoscopy service.

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Longly-attached cap can contribute to en bloc underwater endoscopic mucosal resection of 20-30 mm colorectal intramucosal lesions.

A longly-attached cap might contribute to en bloc resection.

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Quality of life in patients with achalasia: Associations with Eckardt score and objective treatment outcomes after peroral endoscopic myotomy.

Following POEM, a significant and clinically relevant QoL improvement is observed. QoL is associated with ES, but not with objective results after POEM.

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Endoscopy

Evaluation of a real-time computer-aided polyp detection system during screening colonoscopy: AI-DETECT study.

In high-performing colonoscopists in a BCSP who routinely used Endocuff Vision, CADe improved PDR but not ADR. CADe appeared to have limited benefit in a BCSP setting where procedures are performed by experienced colonoscopists.

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Gastrointest Endosc

Artificial intelligence for detecting and delineating the extent of superficial esophageal squamous cell carcinoma and precancerous lesions under narrow band imaging.

The proposed AI system could accurately detect superficial ESCC and precancerous lesions and delineate the extent of lesions under NBI.

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Endoscopic management of patients with high-risk colorectal colitis-associated neoplasia: a Delphi study.

This is the first step in developing international consensus-based recommendations for endoscopic management of (HR-)CAN. Although the quality of available evidence was considered low, consensus was reached on several aspects of the management of (HR-)CAN. The present work and proposed standardization might benefit future studies.

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Prevalence and Impact of Opioid Use in Patients Undergoing Peroral Endoscopic Myotomy.

In this single center study of 89 patients with type III achalasia, EGJOO, DES, or HE treated with POEM, daily opioid use was present in 20%. Response to POEM and post-POEM GERD were similar between opioid and non-opioid users.

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Randomized trial of contrast-enhanced harmonic guidance versus fanning technique for EUS-guided fine-needle biopsy of solid pancreatic lesions.

The diagnostic accuracy of EUS-FNB with the fanning technique for SPLs was comparable with the contrast guidance technique. Without additional cost, EUS-FNB with the fanning technique may be preferred for SPLs.

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Gut

Cardiovascular disease risk in paediatric and young adult non-alcoholic fatty liver disease.

Compared with matched population controls, children and young adults with biopsy-proven NAFLD had significantly higher rates of incident MACE, including ischaemic heart disease and congestive heart failure. Research to better characterise cardiovascular risk in children and young adults with NAFLD should be prioritised.

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J Hepatol

A phase I/II study of ARO-HSD, an RNA interference therapeutic, for the treatment of non-alcoholic steatohepatitis.

ARO-HSD was well tolerated at doses =200 mg. This proof-of-concept study demonstrated that short-term treatment with ARO-HSD reduces hepatic HSD17ß13 mRNA and protein, which is accompanied by reductions in ALT. Impacts and Implications TRIAL REGISTRATION

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Charting co-mutation patterns associated with actionable drivers in intrahepatic cholangiocarcinoma.

A detailed knowledge of the most prevalent genomic constellations is fundamental to accelerate therapeutic developments in iCCA. Our study provides a valuable resource for feasibility assessment of clinical trials and subgroup analyses, spurs the development of translationally relevant preclinical models, and generates a knowledge ground to anticipate potential resistance mechanisms to targeted therapies in genomically defined subgroups of iCCA patients. Impact and implications Due to the high frequency of targetable alterations, molecular diagnostics is recommended in patients with biliary tract cancers, and especially in those with intrahepatic cholangiocarcinoma. The identification of an actionable lesion, however, does not guarantee for therapeutic success, and the co-mutational spectrum may act as a critical modifier of drug response. Using a large dataset of comprehensive panel sequencing results from 6130 intrahepatic cholangiocarcinoma patients, we provide a detailed analysis of the co-mutational spectrum of the most frequent druggable genetic alterations, that is meant to serve as a reference to establish genetically relevant preclinical models, develop hypothesis driven combination therapies and identify recurrent genetic profiles.

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Defining the serum proteomic signature of hepatic steatosis, inflammation, ballooning and fibrosis in nonalcoholic fatty liver disease.

Serum protein scanning identified signatures corresponding to the key components of liver biopsy in NAFLD. The models developed were sufficiently sensitive to characterize the longitudinal change for three different drug interventions. These data support continued validation of these proteomic models to enable a "liquid biopsy"-based assessment of NAFLD.

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Neurogastroenterol Motil

Glyphosate affects the neurochemical phenotype of the intramural neurons in the duodenum in the pig.

It may be a first preclinical symptom of digestive tract dysfunction in the course of glyphosate intoxication and further studies are needed to assess the toxicity and risks of glyphosate to humans.

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Somatization is associated with altered serum levels of vitamin D, serotonin, and brain-derived neurotrophic factor in patients with predominant diarrhea irritable bowel syndrome.

These data support the multifactorial IBS pathogenesis in which organic and psychological factors interact. An active role by VD, 5-HT, and BDNF in affecting the clinical and biochemical profiles in IBS-D(S+) patients may be conceivable. Therefore, the routine VD estimation and the assay of circulating levels of 5-HT and BDNF could be considered a new approach for managing these patients.

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Spanish translation and validation of a hybrid, health-related quality of life questionnaire for chronic esophageal conditions: NEQOL-S.

The translated and cross-culturally adapted NEQOL-S showed good psychometric properties that allow its use in Spanish-speaking patients suffering from CEC.

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The influence of supragastric belching severity on esophageal acid exposure and motility.

Supragastric belching is common, associated with higher incidence of IEM and is responsible for almost a third of esophageal acid burden. The impact of SGB is proportional to its severity. Diagnosis of SGB should be sought in patients with excessive belching and in patients with refractory reflux symptoms. Recognizing SGB and treating patients with behavioral therapy may alleviate acid exposure and improve quality of life.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Clin Gastroenterol Hepatol

Treating Itch in Primary Biliary Cholangitis: A GLIMMER of Hope That Needs a Nugget of Validation.

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Endosc Int Open

EUS-guided treatments of pancreatic cystic neoplasms - a call for methodological improvements.

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Gastrointest Endosc

Automated artificial intelligence scoring systems for the endoscopic assessment of ulcerative colitis: How far are we from clinical application?

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Letter from the new GIE Editor-in-Chief.

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Topical hemostatic agents for malignancy-related GI bleeding: Is it time to prioritize their use?

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J Hepatol

Acknowledging our reviewers.

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Beta-blockers in the era of precision medicine in patients with cirrhosis.

The clinical risk-to-benefit ratio appears to deteriorate in advanced decompensated stages and the risk of harm is high in patients with refractory ascites, low blood pressure and renal impairment, which clinically define closure of the therapeutic window. We also critically review non-invasive surrogates and biomarkers for predicting the haemodynamic response to NSBBs and confirm that the absence of reliable non-invasive methods is one of the main challenges facing the field.

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NAFLD and NASH Biomarker Qualification in the LITMUS consortium - Lessons learned.

Sharing knowledge of such interactions with the scientific community is of paramount importance to increase the chances of qualification of relevant biomarkers that may accelerate drug development, and thereby help patients, across disease indications. A qualified biomarker enables a decision to be made that al understand and support in a common framework.

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Neurogastroenterol Motil

Electrical devices for functional visceral pain.

In addition to motor effects, there were also significant effects on GERD symptoms, raising the question whether extrinsic electrical nerve stimulation of the gut can reduce symptoms through effects that target sensation. This brief review summarizes evidence regarding the application of electrical acustimulation, transauricular electrical stimulation, and sacral electrical or magnetic stimulation to reduce abdominal or pelvic pain.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Am J Gastroenterol

A Rare Cause of Dyschezia in a Young Man: Cholecystocolic Fistula with Huge Gallstone Migrated to the Rectum.

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Endoscopic resection of a complex recto-sigmoid lesion using novel technology to prevent long term luminal stricture.

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Madame Bouveret: Duodenal Obstruction due to a Large Isoattenuating Gallstone.

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Clin Gastroenterol Hepatol

Development and Implementation of a Hepatocellular Carcinoma Surveillance Quality Metric.

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Neoadjuvant chemotherapy and endoscopic resection for hypopharyngeal cancer.

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Opioid Prescription Patterns and Disparities during Ambulatory Encounters in Patients with Cirrhosis.

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Endosc Int Open

A novel technique to improve endoscopic accessibility in laparoscopic endoscopic cooperative surgery for a duodenal lesion.

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Detecting remnant sessile serrated lesion after piecemeal cold snare polypectomy using acetic acid with narrow-band imaging.

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Endoscopy

A novel controllable catheter with a short flexible tip for guidewire insertion in severe malignant hilar biliary stricture.

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A novel endoscopy training system by video-based asynchronous communication.

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Capsule endoscopy successfully diagnosed Henoch-Schönlein Purpura in a patient with small intestine involvement.

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Emergency call: "Doctor I swallowed a stick".

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Endoscopic closure of a gastric perforation using mucosal adaptative ring to close endoscopic artificial ulcer: the MARCEAU system.

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Endoscopic full-thickness resection preserving the mucosa: more is better.

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Endoscopic management of bleeding after endoscopic ultrasound-guided drainage of a pancreatic pseudocyst.

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Endoscopic strictureplasty for severe colonic anastomotic stricture.

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Endoscopic ultrasound-guided drainage of a liver abscess with a self-expandable metal stent as rescue therapy after plastic stent misdeployment.

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From darkness to brightness: the cholangioscopy-guided selective biliary cannulation with the help of transparent cap during ERCP.

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Gastric endoscopic submucosal dissection assisted by intralesional cross-traction using silicone bands.

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Lumen-apposing metal stent gastrojejunostomy for biliary drainage of an obstructive biliodigestive anastomosis.

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The "tapping-a-screw method" for endoscopic removal of an incarcerated pancreatic duct stone using a novel screw-shaped dilator with a 0.018-inch guidewire.

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The "zipline" technique for endoscopic removal of a migrated pancreatic stent.

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Thread a needle with two hands: inner countertraction using clip with rubber band facilitates difficult pancreatic cannulation during ERCP.

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Three pancreatic duct lesions in one patient found at an early stage by cholangioscopy.

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Traction by dental floss loop for adequate submucosal dissection depth in a rectal neuroendocrine tumor.

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Transcolonic endoscopic ultrasound-guided fine-needle biopsy to diagnose a pancreatic tail adenocarcinoma in a patient with surgically altered anatomy.

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Underwater and traction-assisted endoscopic submucosal dissection in the gastric fundus using a multibending endoscope.

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Virtual scale endoscope-assisted wide-field resection of large sessile serrated lesions.

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Gastroenterology

A case of a curious skin lesion.

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A Giant Cystic Liver Mass in an Elderly Male.

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A rare case of hyponatremia and gallbladder cancer.

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A Shallow and Large Ulcer on the Ileocecal Valve in a Young Man with Ulcerative Proctitis.

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Abdominal compartment syndrome after binge eating.

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An Unusual Case of Hematemesis.

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An Unusual Case of Intermittent Fever With Multiple Liver Lesions.

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An Unusual Case of Significant Cervical Esophageal Stricture.

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Barriers and Facilitators to Genetic Education, Risk Assessment, and Testing: Considerations on Advancing Equitable Genetics Care.

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Computer-aided detection of polyps does not improve colonoscopist performance in a pragmatic implementation trial.

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Impact of Helicobacter Pylori Eradication on Incidence of Peptic Ulcer Bleeding in Patients Taking Regular Aspirin.

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Laryngo-pharyngeal lesion appeared in a patient with eosinophilic esophagitis.

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Liver Mass: Island-like sign.

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Training Generations of Clinician Educators: Applying the Novel Clinician Educator Milestones to Faculty Development.

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We are what we eat: the association between ultra-processed food consumption, colon cancer risk and all-cause mortality.

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Gastrointest Endosc

Dislodged Lumen-Apposing Metal Stent (LAMS) in Endoscopic Ultrasound Guided Gastrojejunostomy (EUS- GJ) salvaged by LAMS-in-LAMS technique.

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Once is by chance, two is a trend: A recurring finding within the post-resection defect.

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Gut

Bad gut feeling: a case of recurrent abdominal pain in a young man.

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J Hepatol

From the Editor's Desk….

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Letters&Replies

Letters to the editors and authors’ replies

Clin Gastroenterol Hepatol

Response to the "Letter to the Editor, Nonalcoholic fatty liver disease without metabolic-associated fatty liver disease and metabolic syndrome".

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Gastrointest Endosc

Gastric juice accelerates liquefaction of pancreatic necrosis.

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Limitations in endoscopic sleeve gastroplasty outcomes data derived from surgery-based repositories.

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The potential role of artificial intelligence besides predicting gastric cancer invasion depth.

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J Hepatol

Expert opinion versus meta-analysis: to be or not to be? Authors' reply.

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G-CSF exacerbates liver injury in a mouse model of autoimmune hepatitis.

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Global prediction of primary liver cancer incidences and mortality in 2040.

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More efforts to explore the association between cirrhosis and COVID-19 mortality, and the association between NAFLD and severe COVID-19.

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Reply to "Factor VIII as a potential predictor of recurrent thrombosis in patients with non-cirrhotic portal vein thrombosis".

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Screening for NAFLD and its severity in type 2 diabetic patients: value of magnetic resonance imaging and outstanding issues.

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The value of surrogate endpoints and predictive markers in autoimmune hepatitis.

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Neurogastroenterol Motil

Chagas Disease esophagopathy may help understand Type II achalasia with focal elevated pressures. Comment on: Low et al.'s Type II achalasia with focal elevated pressures: A distinct manometric and clinical subgroup.

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